Chromogranin B EURIA

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Chromogranins are soluble secretory proteins which are stored in the majority of different neuroendocrine cells. Increased levels in the circulation can be used as a general marker for various neuroendocrine tumours. Typical neuroendocrine tumours are carcinoid tumours, phaeochromcytomas, neuroblastomas, small cell lung cancers, hyperparathyroid adenomas, and pituitary tumours. This also includes the different neuroendocrine tumour syndromes, namely the gastrinomas, insulinomas, glucagonomas, somatostatinomas, PPomas and the non-functioning neuroendocrine tumours.

Chromogranin A is an established marker for diagnosis and follow-up of treatment for neuroendocrine tumours. Despite its merits as an important diagnostic tool there are some drawbacks of chromogranin A measurements. It is known that chromogranin A levels are often elevated in patients with decreased renal function, patients with atrophic gastritis and in patients on treatment with proton pump inhibitor. These clinical parameters can sometimes impair the clinical use of chromogranin A. To circumvent this problem a test for chromogranin B has been developed. Chromogranin B has been shown to be a diagnostic tool with similar clinical use as chromogranin A and it has been shown that chromogranin B levels are not affected by either proton pump inhibitor treatment or decreased renal function. With its lower sensitivity but very high specificity chromogranin B measurements can serve as a valuable complement to chromogranin A.

Product code
RB 322
Format
RIA
Tests
100
Calibrators
7
Range
0-4 nmol/L
Incubation time
24 h
Tracers
125I-Chromogranin B
Availability
CE marked. Available in US only for research use, not for IVD use

Intended use

The EURIA-Chromogranin B kit is a competitive radioimunoassay (RIA) for determination of chromogranin B in human plasma and serum using antibodies against human chromoganin B.

The analysis should be performed by trained laboratory professionals.

FOR IN VITRO DIAGNOSTIC USE

This product is also available as research use only. Product code: RB 322 RUO

For complete product description, claims and use, please refer to the Instructions For Use. Contact your local representative for availability in your country.