iLite® anti-EGFR ADCC Activity Set

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This product contains a packaged set of the three individual products, one vial of each:
iLite® ADCC Effector (V) Assay Ready Cells (BM5001), 
iLite® ADCC Target EGFR (+) Assay Ready Cells (BM5035) 
iLite® ADCC Target EGFR (-) Assay Ready Cells (BM5036)
 
All three products are genetically engineered human cells to be used for measuring the ADCC activity of anti-EGFR antibodies. 

Product code
BM5080
Format
Assay Ready Cells
Detection system
Luminescence
Availability
Research Use Only (RUO)

The products included in the iLite® anti-EGFR ADCC Activity Set can be used for the quantification ADCC activity of anti-EGFR antibodies.

Antibody-dependent cell-mediated cytotoxicity (ADCC) is a mechanism whereby pathogenic cells are lysed by lymphocytes, most often Natural Killer (NK) cells. The mechanism involves binding of antibodies to surface antigens on the pathogen. Crosslinking of these antibodies to NK cells through the binding of the Fc-portion to Fc receptors on the NK cells leads to activation of the NK cell and formation of an immune synapse with the pathogenic cell. The NK cell releases cytotoxic granules containing granzymes and perforin into the synapse, leading to apoptosis of the targeted cell.

3 vials of iLite® Assay Ready Cells (>250 µL). For contents of the individual vials, please please consult the specific Product Specifications.